Advanced conditioning compounds

Two more ingredients incorporated in Revita.COR lend advanced conditioning properties: biotinyl tripeptide-1 (scalp conditioning) and niacinamide (heterocyclic aromatic compound).

BIOTINYL TRIPEPTIDE-1

A scalp-conditioning agent that stimulates metabolism in skin cells and opposes follicle aging to help prevent hair loss, biotinyl tripeptide-1 enhances production of the binding elements that hold cells together and facilitate the communications otherwise blocked by dihydrotestosterone. It increases cutaneous blood flow, thus restoring nourishment to miniaturizing follicles.

A tripeptide-1 is a protein-derivative molecule containing three amino acid residues: glycerine, histidine, and lysine. Biotinyl tripeptide-1 boosts the synthesis of laminin-5, a glycoprotein and component of connective tissue. It also boosts collagen IV, a fibrous protein, the chief constituent of fibrils, and the organic substance of bones.

These activities are especially important at the junction of the dermis and epidermis, an area where cells are highly engaged in the reproductive process and where dihydrotestosterone can do great damage.

In a four-month clinical study with 35 male volunteers suffering from alopecia, 18 applied a hair lotion containing biotinyl tripeptide-1, and 17 applied a placebo. After treatment, the ratio of hairs in anagen growth phase versus telogen resting phase increased for 67 percent of the volunteers, and it increased by up to 46 percent. The root sheath was thicker to ensure optimum anchoring.

NIACINAMIDE

In living organisms, niacinamide is converted to and from niacin and is used similarly. A constituent of vitamin B3, it occurs naturally in yeasts and other foods. In biotechnical formulations, niacinamide, also called nicotinamide, is a heterocyclic aromatic compound that functions as a conditioning agent.

Benefits of niacinamide for the treatment of skin conditions have received greater study over the last few years, and the crystalline basic amide is now formulated into advanced products for moisturization, antiaging, and rosacea. The compound is used in premium hair conditioners, hand creams, paste masks, lotions, powders, and sprays.

Both niacinamide and niacin are absorbed easily through skin, and dermal toxicity studies have not identified any significant adverse effects. Clinical tests of niacinamide produced no stinging sensations even at high concentration. The compound is not an irritant, sensitizer, or photosensitizer.

Niacinamide and niacin are approved by the strict Japanese and European regulatory authorities for topical application. In fact, niacinamide has even been found to moderate the effects of established carcinogens.