BIO-ADHESIVE TECHNOLOGY IN REVITA.COR
Unique among conditioners, Revita.COR optimizes hair-growth benefits even while swimming or sweating because it delivers its active ingredients within hydrophobic, bio-adhesive, cationically charged microspheres less than a micron in diameter.
This delivery system’s tiny particle size, from 0.1 to 1.0 μm, allows penetration of the hair, skin, and follicles deeper than with any other system. Encapsulated within these next-generation vehicles, active compounds adhere to the scalp tenaciously and work effectively long after the hair has been rinsed — 12 hours or more.
The solid state of the microspheres helps not only to repel water but also to increase stability and prolong product life. It allows ingredients to be released slowly over time. It protects the active compounds within the spheres and reduces their reaction with environmental factors.
Revita.COR possesses these properties because its bio-adhesive, positively charged microspheres cling to the abundant proteinaceous material that makes up hair and scalp.
In a clinical trial, human hair was treated with a shampoo containing either a 1% free-form compound or a 1% bio-adhesive, cationically charged, encapsulated version of the same compound. Then the hair samples were analyzed by gas chromatography, mass spectrometry, measurement of fragrance in the headspace, and subjective evaluation by a panel of olfactory experts.
At 24 hours, the encapsulated ingredient was 10 times stronger than the free-form ingredient. It also persisted longer.
In another clinical trial, comparing a 6% lotion employing free-form ingredients to a 6% lotion with encapsulation, skin-penetration depth was determined using a skin-extraction technique and chromatographic analysis. One inner forearm was used to test a control sample, and the opposite arm was used to test the encapsulated sample, of which 0.25 grams was applied to a 15.5 cm² zone and left on for one minute. Both arms were rinsed and dried. Then 1.5 ml of ethanol was placed on the skin for 30 seconds, its fraction was collected, and the entire procedure was repeated three times.
Penetration analysis confirmed that twice as much of the free-form ingredient stayed behind on the superficial layers of the skin, while more than twice as much of the ingredient encapsulated in the bio-adhesive, cationically charged microspheres reached down into the lower layers of the skin, where it could perform more effectively.
Release-kinetics analysis also showed that more of the active ingredient persisted after two, four, and six hours, whereas more of the free-form ingredient had dissipated.